ENZYMES and REACTIONS: Each line corresponds to a reaction, identified by a number, and by the enzyme that mediates it. After the colon is the list of metabolites that participate in the reaction. 1.HK: MGATP MG G6P DPG23 2.PGI: G6P F6P 3.G6PDH: NADPH G6P GL6P 4.PFK: F6P MGATP ATP AMP 5.TALD: S7P GAP E4P F6P 6.ALD: FDP GAP DHAP 7.TPI: DHAP GAP 8.GAPDH: GAP NADH DPG13 9.TKI: X5P R5P GAP S7P 10.TKII: X5P E4P GAP F6P 11.PGK: DPG13 ADP PG3 ATP 12.DPGM: DPG13 DPG23 13.DPGase: DPG23 14.PGM: PG3 PG2 15.EN: PG2 PEP 16.PK: MGADP PEP ATP FDP 17.PEX: PYR 18.LDH: PYR NADH LAC 19.LEX: LAC 20.AMPase: AMP 21.ADA: ADO 22.AK: ATP ADO 23.ADK: MG ADP ATP AMP 24.AMPDA: AMP 25.ATPase: ATP 26.ADPRT: ADE PRPP 27.PGLase: GL6P 28.GL6PDH: GO6P RU5P NADPH 29.GSSGR: NADPH GSH 30.GSHR: GSH 31.RU5PI: RU5P R5P 32.XU5PE: RU5P X5P 33.IMPase: IMP INO 34.PNPase: INO R1P HX 35.PRM: R1P R5P 36.PRPPSYN: R5P ATP PRPP AMP 37.HGPRT: PRPP HX 38.HXEX: HX 39.ADEEX: ADE 40.ADOEX: ADO 41.INOEX: INO 42.KLEAK: KI 43.NALEAK: NAI 44.PUMP: NAI ATP METABOLITES: Each metabolite is followed by the list of reactions it participates in (in parentheses), and then by the list of all metabolites it is coupled to by these reactions. 1. G6P (HK - PGI - G6PDH): MGATP MG G6P DPG23 F6P NADPH GL6P 2. F6P (PGI - PFK +TALD +TKII): G6P F6P MGATP ATP AMP S7P GAP E4P X5P 3. FDP (PFK - ALD): F6P MGATP ATP AMP FDP GAP DHAP 4. DHAP (ALD - TPI): FDP GAP DHAP 5. GAP (ALD + TPI - GAPDH + TKI + TKII - TALD): FDP GAP DHAP NADH DPG13 X5P R5P S7P E4P F6P 6. DPG13 (GAPDH - PGK - DPGM): GAP NADH DPG13 ADP PG3 ATP DPG23 7. DPG23 (DPGM - DPGase): DPG13 DPG23 8. PG3 (PGK - PGM + DPGase): DPG13 ADP PG3 ATP PG2 DPG23 9. PG2 (PGM - EN): PG3 PG2 PEP 10. PEP (EN - PK): PG2 PEP MGADP ATP FDP 11. PYR (PK - PEX - LDH): MGADP PEP ATP FDP PYR NADH LAC 12. LAC (LDH - LEX): NADH LAC 13. NADH (GAPDH - LDH): NADH LAC GAP DPG13 14. GL6P (G6PDH - PGLase): G6P GL6P NADPH 15. GO6P (PGLase - GL6PDH): GL6P GO6P RU5P NADPH 16. NADPH (-GSSGR + G6PDH + GL6PDH): G6P GL6P NADPH GO6P RU5P GSH 17. GSH (2*GSSGR - GSHR): NADPH GSH 18. RU5P (GL6PDH - RU5PI - XU5PE): GO6P NADPH RU5P R5P X5P 19. R5P (RU5PI - TKI +PRM - PRPPSYN): RU5P R5P X5P GAP S7P R1P ATP PRPP AMP 20. X5P (XU5PE - TKI - TKII): RU5P X5P R5P GAP S7P E4P F6P 21. S7P (TKI - TALD): X5P R5P GAP S7P E4P F6P 22. E4P (TALD - TKII): X5P E4P GAP F6P S7P 23. ADO (AMPase - ADA - AK - ADOEX): AMP ADO ATP 24. AMP (ADPRT +AK +ADK - AMPase - AMPDA +PRPPSYN): R5P ATP PRPP AMP ADO ADE ADP MG 25. ADP (HK +PFK - PGK - PK +AK - 2*ADK +ATPase + PUMP: MGATP MG G6P DPG23 F6P ATP AMP PEP FDP ADO ADP DPG13 PG3 MGADP NAI 26. ATP (PK +PGK - HK - PFK +ADK - AK -PRPPSYN - ATPase - PUMP): R5P ATP PRPP AMP ADO ADP MGATP MG G6P DPG23 F6P DPG13 PG3 MGADP PEP FDP NAI 27. PRPP (PRPPSYN - ADPRT - HGPRT): R5P ATP PRPP AMP ADE HX 28. IMP (AMPDA - IMPase +HGPRT): AMP PRPP HX IMP 29. INO (IMPase +ADA - PNPase-INOEX): ADO IMP INO R1P HX 30. HX (PNPase - HXEX - HGPRT): PRPP HX INO R1P 31. R1P (PNPase - PRM): R1P R5P INO HX 32. ADE (-ADPRT - ADEEX): ADE PRPP 33. NAI (NALEAK - 3*PUMP): NAI ATP 34. KI (KLEAK + 2*PUMP): KI NAI ATP 35. MGATP (-MGATP+(ATP MG)/(MG+mgatpk)): MGATP ATP MG 36. MGADP (-MGADP+(ADP MG)/(MG+mgadpk)): MGADP ADP MG 37. MGAMP (-MGAMP+(AMP MG)/(MG+mgampk)): MGAMP AMP MG 38. MGDPG23 (-MGDPG23+(DPG23 MG)/(MG+mgdpgk)): MGDPG23 DPG23 MG 39. MG (MG + (AMP MG)/(MG+mgampk) + (ADP MG)/(MG+mgadpk) + (ATP MG)/(MG+ mgatpk) + (DPG23 MG)/(MG+mgdpgk) - MGT): MG AMP ADP ATP DPG23