https://nemenmanlab.org/~ilya/index.php?action=history&feed=atom&title=P53_regulationP53 regulation - Revision history2026-05-17T09:38:43ZRevision history for this page on the wikiMediaWiki 1.31.0https://nemenmanlab.org/~ilya/index.php?title=P53_regulation&diff=783&oldid=prevIlya: 1 revision imported2018-07-04T16:28:45Z<p>1 revision imported</p>
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</td></tr></table>Ilyahttps://nemenmanlab.org/~ilya/index.php?title=P53_regulation&diff=782&oldid=prevnemenman>Ilya: /* References */2007-10-08T15:50:41Z<p><span dir="auto"><span class="autocomment">References</span></span></p>
<p><b>New page</b></p><div>p53 is one of very important and very well studied regulatory systems, where effects of stochasticity have been noted. p53 responds to DNA damage in a digital matter, meaning that it pulses, and the number of pulses corresponds to the severity of the damage. Stochastic effects seem to be critical in determining reproducibility of the number of these oscillations. Interestingly, this system provides one of very few examples where a systems biology model is actually ''predictive'' in a common sense, allowing understanding of a phenomenon.<br />
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==References==<br />
# L Ma, J Wagner, JJ Rice, W Hu, A Levine, and G Stolovitzky. A plausible model for the digital response of p53 to DNA damage. ''PNAS'' '''102''':14266, 2005. [[media:ma-etal-05.pdf | PDF]], [http://www.pnas.org/cgi/content/full/0501352102/DC1 Supplementary]. <br />
# W Hu, Z Feng, L Ma, J Wagner, JJ Rice, G Stolovitzky, and A Levine. A Single Nucleotide Polymorphism in the MDM2 Gene Disrupts the Oscillation of p53 and MDM2 Levels in Cells. ''Cancer Res'' '''67''':2757, 2007. [[media:hu-etal-07.pdf | PDF]].<br />
# J Wagner, L Ma, JJ Rice, W Hu, A Levine, and G Stolovitzky. p53 – Mdm2 loop controlled by a balance of its feedback strength and effective dampening using ATM and delayed feedback. ''IEE Proc. Syst. Biol.'' '''152''':109, 2005. [[media:wagner-etal-05.pdf | PDF]].<br />
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[[Category:Literature review]]</div>nemenman>Ilya