Nemenman and Wiggins

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I Nemenman and C Wiggins. On geometric measures of regulatory complexity, In preparation.

Abstract

Transcriptional regulation of a gene in a network can be characterized by a vector that counts numbers of binding sites in its promoter region where a protein product of every other gene can bind. We analyze the distribution of such vectors for S. cerevisiae and notice that these form an interesting low dimensional structure. This is significant since in this case one should be able to effectively use similarity of promoter regions and expression profiles as aids for the reconstruction of transcriptional networks.